• Herbimycin A packaged and labeled.

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SKU: H002

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Description

Herbimcyin is a sparingly soluble benzoquinone anti-tumor agent which interacts with the stress-induced chaperone protein Hsp90 (heat shock protein 90).

    CAS Number

    70563-58-5

    Molecular Formula

    C30H42N2O9

    Molecular Weight

    574.66

    Mechanism of Action

    Herbimycin A binds specifically to the heat shock protein Hsp90 and to its endoplasmic reticulum homologue GP96, and thus interferes with conformational maturation of proteins and the cellular stress response.

    Storage Conditions

    -20┬░C

    Tariff Code

    2941.90.1050

Applications

    Cancer Applications

    In normal cells, Hsp90 stabilizes and folds proteins, however, in tumor cells, Hsp90 activity helps stabilize mutated growth factor and signal proteins which facilitate tumor growth. To prevent this complication, Herbimycin A binds to and inactivates Hsp90 in cancerous cells leading to degradation of cancer cell proteins.

Specifications

    Form

    Powder

    Appearance

    Yellow powder

    Source

    Streptomyces hygroscopicus

References

    References

    Eichhorn, Kai. "Geldanamycin: The Prototype of a Class of Antitumor Drugs Targeting the Heat Shock Protein 90 Family of Molecular Chaperones." Cell Stress Chaperones6.2 (2001): 105-12. www.ncbi.gov. Web. 6 Sept. 2012.

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