• Guanidine thiocyanate packaged and labeled.

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SKU: G019

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Description

Guanidine thiocyanate is a freely soluble chaotropic agent routinely used for DNA/RNA extraction protocols.

This product is considered a dangerous good. Quantities above 1 g may be subject to additional shipping fees. Please contact us for specific questions. 

    CAS Number

    593-84-0

    Molecular Formula

    CN3H5 •HSCN

    Molecular Weight

    118.16

    Mechanism of Action

    Extraction of cellular DNA and RNA releases DNase and RNase proteins which function by denaturing DNA and RNA respectively. Guanidine thiocyanate is a preferred chemical to use during cell lysis because of its ability to irreversibly inactivate these degrading nucleases. In addition to its chaotropic properties, guanidine thiocyanate has also shown to inactivate enveloped viruses and some non-enveloped viruses.

    Storage Conditions

    2-8 °C

    Tariff Code

    2925.29.9000

Applications

    Microbiology Applications

    Guanidine thiocyanate is routinely used for DNA/RNA extraction protocols to prevent damage by degredative enzymes.

Specifications

    Form

    Powder

    Appearance

    White crystalline powder

    Source

    Synthetic

    Ammonia

    Not more than 0.05%

    Absorbance

    (6M) 280nm : ≤0.5

    pH

    (6M): 4.5-6.0

    Melting Point

    115-122 °C

    Loss on Drying

    ≤0.3%

References

    References

    Roberts, P. L. "Virus Inactivation by Protein Denaturants Used in Affinity Chromatography." Biologicals: Journal of the International Association of Biological Standardization 35.4 (2007): 343-47. Ncbi.gov. 24 May 2007. Web. 12 Sept. 2012.

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