• Geldanamycin packaged and labeled in glass bottle.

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SKU: G005

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Description

Geldanamycin is a benzoquinone anti-tumor agent which interacts with the stress induced chaperone protein Hsp90 (heat shock protein 90). Geldanamycin is insoluble in aqueous solution but soluble in DMSO and methanol.

    CAS Number

    30562-34-6

    Molecular Formula

    C29H40N2O9

    Molecular Weight

    560.64 g/mol

    Mechanism of Action

    Geldanamycin binds specifically to the heat shock protein Hsp90 and to its endoplasmic reticulum homologue GP96, and thus interferes with conformational maturation of proteins and the cellular stress response. In addition, it is a potent inhibitor of the nuclear hormone receptor family.

    Storage Conditions

    -20 °C, protect from light

    Tariff Code

    2941.90.1050

Applications

    Cancer Applications

    In normal cells, Hsp90 stabilizes and folds proteins, however, in tumor cells, Hsp90 activity helps stabilize mutated growth factor and signal proteins which facilitate tumor growth. To prevent this complication, geldanamycin binds to and inactivates Hsp90 in cancerous cells leading to degradation of cancer cell proteins.

Specifications

    Form

    Powder

    Appearance

    Yellow to orange powder

    Source

    Streptomyces Hygroscopicus

    Melting Point

    201-203°C

References

    References

    Eichhorn, Kai. "Geldanamycin: The Prototype of a Class of Antitumor Drugs Targeting the Heat Shock Protein 90 Family of Molecular Chaperones." Cell Stress Chaperones6.2 (2001): 105-12. www.ncbi.gov. Web. 6 Sept. 2012.

     

     

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