• Flumequine packaged and labeled.

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SKU: F011

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Description

Flumequine is a first generation fluoroquinolone antibiotic commonly used in veterinary medicine for enteric infections. Flumequine is freely soluble in dilute solutions of alkali hydroxides.

    CAS Number

    42835-25-6

    Molecular Formula

    C14H12FNO3

    Molecular Weight

    261.25

    Mechanism of Action

    Fluoroquinolone antibiotics target bacterial DNA gyrase, an enzyme which reduces DNA strain during replication. Because DNA gyrase is required during DNA replication, subsequent DNA synthesis and ultimately cell division is inhibited.

    Storage Conditions

    Ambient

    Tariff Code

    2933.99.7900

    Spectrum

    Flumequine targets primarily gram negative bacteria, especially those which cause enteric infections in animals.

Applications

    Microbiology Applications

    Flumequine is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Escherichia coli 0.12 µg/mL – 0.5 µg/mL
    • For a complete list of flumequine MIC values, click here.

Specifications

    Form

    Powder

    Appearance

    White Crystalline Powder

    Source

    Synthetic

    Impurity Profile

    Impurity A| (RS)-5-methyl-1-oxo-6,7-dihydro-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid (defluoroflumequine)|||| Impurity B| ethyl (RS)-9-fluoro-5-methyl-1-oxo-6,7-dihydro-1H,5H-benzo[i,j]quinolizine-2-carboxylate (flumequine ethyl ester)||||

    Melting Point

    253-255°C

    Optical Rotation

    -0.1° to +0.1°

    Assay

    (On Dried Basis): 99.0-101.0%

    Loss on Drying

    ≤0.5%

References

    References

    Wolfson, John S., and David C. Hooper. "The Fluoroquinolones: Structures, Mechanisms of Action and Resistance, and Spectra of Activity in Vitro." American Society for Microbiology 4th ser. 28 (1985): 581-86.

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