• Enrofloxacin hydrochloride packaged and labeled.

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SKU: E007

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Description

Enrofloxacin is a fluoroquinolone antibiotic commonly used in veterinary medicine. Enrofloxcin is slightly soluble in aqueous solution and enrofloxacin HCl is freely soluble at 10 mg/mL.

TOKU-E offers two forms of enrofloxacin:

Poller et al. used enrofloxacin HCl from TOKU-E to study "Influence of different surface chemistries on the ultrasensitive on-chip detection of enrofloxacin in milk"

 

    CAS Number

    112732-17-9

    Molecular Formula

    C19H22FN3O3 •HCl

    Molecular Weight

    395.86

    Mechanism of Action

    Fluoroquinolone antibiotics target bacterial DNA gyrase, an enzyme which reduces DNA strain during replication. Because DNA gyrase is required during DNA replication, subsequent DNA synthesis and ultimately cell division is inhibited.

    Storage Conditions

    <30°C

    Tariff Code

    2933.59.3600

    Spectrum

    Enrofloxacin is a broad spectrum antibiotic targeting a wide variety of gram positive and gram negative bacteria and a few Mycoplasma species.

Applications

    Microbiology Applications

    Enrofloxacin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive, gram negative, and certain Mycoplasma species. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Pseudomonas aeruginosa 0.5 µg/mL – 2 µg/mL
    • Escherichia coli 0.004 µg/mL – 0.03 µg/mL
    • For a complete list of enrofloxacin MIC values, click here.

Specifications

    Form

    Powder

    Appearance

    Almost White Crystalline Powder

    Source

    Synthetic

    Elemental Analysis

    Fluoride: ≥4.5%

    Impurity Profile

    Impurity A| 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid|||| Impurity B| ciprofloxacin|||| Impurity C| 1-cyclopropyl-7-(4-ethylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid|||| Impurity E| 6-chloro-1-cyclopropyl-7-(4-ethylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid|||| Impurity F| 1-cyclopropyl-7-(4-ethylpiperazin-1-yl)-6-fluoroquinolin-4(1H)-one|||| Impurity G| 7-[(2-aminoethyl)amino]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid||||

    pH

    3.5-4.5

    Assay

    (On Dried Basis): ≥98.5%

    Loss on Drying

    ≤1.0%

References

    References

    Wolfson, John S., and David C. Hooper. "The Fluoroquinolones: Structures, Mechanisms of Action and Resistance, and Spectra of Activity in Vitro." American Society for Microbiology 4th ser. 28 (1985): 581-86.

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