• Doripenem hydrate

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SKU: D004

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Description

Doripenem is a β-lactam antibiotic in the carbapenem class and is sparingly soluble in aqueous solution. Doripenem has been found to be effective against extended spectrum beta-lactamase (ESBL) producing Enterobacteriaceae; a microbe resistant to many first line beta-lactam antibiotics and certain cephalosporins.

    CAS Number

    364622-82-2

    Molecular Formula

    C15H24N4O6S2•H2O

    Molecular Weight

    438.52

    Mechanism of Action

    β-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases; however, carbapenems, including doripenem, are highly resistant to β-lactamases.

    Storage Conditions

    2-8 °C

    Tariff Code

    2941.90.5000

    Spectrum

    Doripenem is a broad spectrum antibiotic targeting a wide range of gram positive and gram negative bacteria including Pseudomonas aeruginosa.

Applications

    Microbiology Applications

    Doripenem is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates.  Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients.  Representative MIC values include:

    • Bacteroides fragilis 0.125 µg/mL – 8 µg/mL
    • Pseudomonas aeruginosa 8 µg/mL - 32 µg/mL
    • For a complete list of doripenem MIC values, click here.

Specifications

    Form

    Powder

    Melting Point

    >186 °C

References

    References

    Guzmán, Flavio, MD. "Beta Lactams Antibiotics (penicillins and Cephalosporins) Mechanism of Action.” Medical Pharmacology. Pharmacology Corner, 29 Nov. 2008. Web. 21 Aug. 2012.

    Pitout JD, Sanders CC, Sanders WE Jr. Antimicrobial resistance with focus on beta-lactam resistance in gram-negative bacilli. Am J Med 1997; 103:51.

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