• Difloxacin hydrochloride packaged and labeled.

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SKU: D021

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Description

Difloxacin HCl is a fluoroquinolone antibiotic commonly used in veterinary medicine. Difloxacin HCl is freely soluble in aqueous solution (5 mg/mL).

    CAS Number

    91296-86-5

    Molecular Formula

    C21H19F2N3O3 •HCl

    Molecular Weight

    435.85

    Mechanism of Action

    Fluoroquinolone antibiotics target bacterial DNA gyrase, an enzyme which reduces DNA strain during replication. Because DNA gyrase is required during DNA replication, subsequent DNA synthesis and ultimately cell division is inhibited.

    Storage Conditions

    <30°C

    Tariff Code

    2933.59.3600

    Spectrum

    Difloxacin is a broad spectrum antibiotic targeting a wide variety of Gram negative and Gram positive bacteria. In addition, Difloxacin is also effective against a few Mycoplasma species including Mycobacterium tuberculosis.

Applications

    Microbiology Applications

    Difloxacin HCl is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram positive and Gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients.Representative MIC values include:

    • Mycobacterium tuberculosis 0.5 µg/mL – 8 µg/mL
    • Escherichia coli 0.1875 µg/mL
    • For a complete list of difloxacin MIC values, click here.

Specifications

    Form

    Powder

    Appearance

    White or cream-colored crystalline powder

    Elemental Analysis

    Fluoride: ≥7.8%

    pH

    3.0-5.0

    Assay

    (On Dried Basis): ≥98.0%

    Loss on Drying

    ≤3.0%

    Residue On Ignition

    ≤0.1%

    Heavy Metals

    ≤20 ppm

References

    References

    Wolfson, John S., and David C. Hooper. "The Fluoroquinolones: Structures, Mechanisms of Action and Resistance, and Spectra of Activity in Vitro." American Society for Microbiology 4th ser. 28 (1985): 581-86.

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