• D-Cycloserine packaged and labeled.

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SKU: C041

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Description

D-cycloserine is an amino acid analog antibiotic. D-cycloserine acts as a competitive inhibitor of D-alanine, an essential amino acid during peptidoglycan synthesis. D-cycloserine is soluble in aqueous solution.

    CAS Number

    68-41-7

    Molecular Formula

    C3H6N2O2

    Molecular Weight

    102.09

    Mechanism of Action

    D-Cycloserine inhibits cell wall biosynthesis (D-Ala peptide bond formation). The terminal two amino acid residues of the murein precursor lipid II consist of D-alanine, which is produced by the enzyme alanine racemase; the two residues are joined by D-alanine ligase. Both enzymes are competitively inhibited by cycloserine.

    Storage Conditions

    -20°C

    Tariff Code

    2941.90.1050

    Spectrum

    D-cycloserine broad spectrum antibiotic but is largely used against bacteria which cause tuberculosis namely Mycobacterium tuberculosis.

Applications

    Microbiology Applications

    D-cycloserine can be used as a selective agent in several types of isolation media:

    Perfringens Agar - SFP and TSC selective supplements

    Clostridium difficile agar - Isolation of Clostridium difficile

    m-CP Medium - Membrane C. perfringens Selective Supplement

Specifications

    Form

    Powder

    Appearance

    White to pale white crystalline powder

    Source

    Synthetic

    pH

    5.5-6.5

    Optical Rotation

    +108° to +114°

    Assay

    (As Is): 900μg/mg

    Loss on Drying

    ≤1.0%

    Residue On Ignition

    ≤0.5%

References

    References

    Lambert, Mary P., and Francis C. Neuhaus. "Mechanism of D-Cycloserine Action: Alanine Racemase from Escherichia Coli." Journal of Bacteriology 110.3 (1972): 978-87. www.ncbi.gov. Web. 27 Aug. 2012.

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