• D-Cycloserine packaged and labeled.

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SKU: C041

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Description

D-Cycloserine is an amino acid analog antibiotic. D-cycloserine acts as a competitive inhibitor of D-alanine, an essential amino acid during peptidoglycan synthesis.  It is a broad-spectrum antibiotic that can be used as a selective agent in several types of isolation media.  D-cycloserine is soluble in aqueous solution.

    CAS Number

    68-41-7

    Molecular Formula

    C3H6N2O2

    Molecular Weight

    102.09

    Mechanism of Action

    D-Cycloserine inhibits cell wall biosynthesis, specifically the D-Ala peptide bond formation. It competitively inhibits alanine racemase (which produces D-alanine) and D-alanine ligase, which joins the terminal 2 amino acid residues together. D-cycloserine is a ligand for the N-methyl-D-aspartate (NMDA) glycine receptor and has partial agonist characteristics, and has proven to have pharmacological activity in enhancing extinction memory.

    Storage Conditions

    -20°C

    Tariff Code

    2941.90.1050

    Spectrum

    D-Cycloserine is a broad-spectrum antibiotic that can be used against the causal agent of tuberculosis (Mycobacterium tuberculosis).

Applications

    Microbiology Applications

    D-Cycloserine can be used as a selective agent in several types of isolation media:

    Perfringens Agar - SFP and TSC selective supplements

    Clostridium difficile agar - Isolation of Clostridium difficile

    m-CP Medium - Membrane C. perfringens Selective Supplement

Specifications

    Form

    powder

    Appearance

    white to pale white crystalline powder

    Source

    synthetic

    pH

    5.5-6.5

    Optical Rotation

    +108° to +114°

    Assay

    (As Is): 900μg/mg

    Loss on Drying

    ≤1.0%

    Residue On Ignition

    ≤0.5%

References

    References

    Hood WF,  Compton RP,  and Monahan JB (1989)  D-Cycloserine: A ligand for the N-methyl-D-aspartate coupled glycine receptor has partial agonist characteristics. Neurosci Lett 98(1):91-95  PMID 2540460

    Lambert MP and Neuhaus FC (1972)  Mechanism of D-Cycloserine action: Alanine racemase from Escherichia coli. J. Bacteriol.  110(3):978-987  PMID 4555420

    Peters J and De Vries TJ (2013)  D-Cycloserine administered directly to infralimbic medial prefrontal cortex enhances extinction memory in sucrose-seeking animals. Neurosci.  230:24-30  PMID  23159319

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