• Cycloheximide, Ultrapure packaged and labeled.

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SKU: C071

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Description

Cycloheximide is a protein synthesis inhibitor in eukaryotic cells and is commonly used to prevent fungal growth. 

TOKU-E offers three forms of cycloheximide: cycloheximide (C001), cycloheximide solution (C084), and cycloheximide ultrapure (C071). Cycloheximide solution is dissolved in DMSO at 100 mg/mL. Cycloheximide ultrapure is ≥98% pure and is free of toxic isomers that can potentially kill wanted fungi in a selection media. 

This product is considered a dangerous good. Quantities above 1 g may be subject to additional shipping fees. Please contact us for specific questions.

    CAS Number

    66-81-9

    Molecular Formula

    C15H23NO4

    Molecular Weight

    281.35

    Mechanism of Action

    Cycloheximide prevents ribosomal translocation during translation as shown in a yeast model. Effective doses are present at concentrations around 200 µM to inhibit yeast growth.

    Storage Conditions

    Ambient

    Tariff Code

    2941.90.1050

Applications

    Plant Biology Applications

    Cycloheximide is a frequently used lab reagent to inhibit fungal growth by targeting protein synthesis. In yeast, concentrations of 200 µM have fungicidal effects. (Schneider-Poetsch, 2010).

Specifications

    Form

    Powder

    Appearance

    White or cream-colored powder

    Source

    Streptomyces Griseus

    Potency (on a dry basis)

    ≥900 u/mg (on dried basis)

    Melting Point

    107-120°C

    Loss on Drying

    ≤1.0%

References

    References

    Doyle S.M., Diamond M. and McCabe P.F, 2009, Chloroplast and reactive oxygen species involvement in apoptotic-like programmed cell death in Arabidopsis suspension cultures. Journal of Experimental Botany, Vol. 61, No. 2, pp. 473–482, 2010

    Schneider-Poetsch T., Ju J., Eyler D.E., Dang Y., Bhat S., Merrick W.C., Green R. and Shen B., 2009, Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin. Nature chemical biology, vol 6, march 2010.

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