• Cloxacillin sodium packaged and labeled.

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SKU: C038

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Description

Cloxacillin sodium is a narrow-spectrum β-lactam antibiotic of the penicillin class. Cloxacillin sodium is sparingly soluble in aqueous solution (0.014 mg/mL).

    CAS Number

    7081-44-9

    Molecular Formula

    C19H17ClN3NaO5S · H2O

    Molecular Weight

    475.88 g/mol

    Mechanism of Action

    β-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases. Unlike other members of the penicillin class, cloxacillin is resistant to β-lactamases.

    Storage Conditions

    2-8 °C

    Tariff Code

    2941.10.3000

    Spectrum

    Cloxacillin targets primarily gram positive bacteria, especially β-lactamase producing Staphylococci.

Applications

    Microbiology Applications

    Cloxacillin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive microbial isolates.  Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients.  Representative MIC values include:

    Staphylococcus aureus 0.2 µg/mL – 3.13 µg/mL

Specifications

    Form

    Powder

    Appearance

    White or almost white powder

    Source

    Semi-synthetic

    Water Content (Karl Fisher)

    3.0-5.0%

    pH

    4.5-7.5

    Assay

    ≥ 825 µg/mg (on dried basis)

    Impurities

    Dimethylanilline: Meets the requirements

References

    References

    Guzmán, Flavio, MD. "Beta Lactams Antibiotics (penicillins and Cephalosporins) Mechanism of Action.” Medical Pharmacology. Pharmacology Corner, 29 Nov. 2008. Web. 21 Aug. 2012.

    Pitout JD, Sanders CC, Sanders WE Jr. Antimicrobial resistance with focus on beta-lactam resistance in gram-negative bacilli. Am J Med 1997; 103:51.

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