• Ceftriaxone sodium, USP packaged and labeled.

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SKU: C022

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Description

Ceftriaxone sodium is a third generation cephalosporin antibiotic and is freely soluble in aqueous solution (105 mg/mL).

    CAS Number

    104376-79-6

    Molecular Formula

    C18H16N8Na2O7S3 · 3.5 H2O

    Mechanism of Action

    Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases. Like many cephalosporins, ceftriaxone is resistant to a number of β-lactamases.

    Storage Conditions

    -20°C

    Tariff Code

    2941.90.5000

    Spectrum

    Ceftriaxone sodium is a broad spectrum antibiotic targeting a wide variety of gram positive and gram negative bacteria.

Applications

    Microbiology Applications

    Ceftriaxone sodium is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Streptococcus pneumoniae 0.03 µg/mL - 8 µg/mL
    • Streptococcus pyogenes 0.008 µg/mL – 0.5 µg/mL
    • For a complete list of ceftriaxone MIC values, click here.

Specifications

    Form

    Powder

    Appearance

    Almost white or yellowish crystalline powder

    Source

    Synthetic

    Water Content (Karl Fisher)

    8.0-11.0%

    pH

    6.0-8.0

    Assay

    (On Dried Basis): ≥795 µg/mg

    Residual Solvents

    N,N-Dimethylanilline: Not more than 20ppm
    2-Ethylhexanoic acid: Not more than 0.8%

Technical Data

Georgopapadakou, N. H. "Mechanisms of Action of Cephalosporin 3'-quinolone Esters, Carbamates, and Tertiary Amines in Escherichia Coli." American Society for Microbiology 37.3 (1992): 559-65. Antimicrobial Agents and Chemotherapy. Web. 21 Aug. 2012.

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