• Ceftibuten packaged and labeled.

click on thumbnail to zoom
SKU: C069

Size  
Quantity:
  Click 'Bulk Order' for 10 or more
Price: make selection(s)
Description

Ceftibuten is a third generation cephalosporin antibiotic.  Ceftibuten is freely soluble in aqueous solution (70.5 mg/mL).

    CAS Number

    97519-39-6

    Molecular Formula

    C15H14N4O6S2

    Molecular Weight

    410.42 g/mol

    Mechanism of Action

    Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases.

    Storage Conditions

    -20°C

    Tariff Code

    2941.90.5000

    Spectrum

    Ceftibuten is a broad spectrum antibiotic targeting a wide variety of gram positive and gram negative bacteria.

Applications

    Microbiology Applications

    Ceftibuten is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Haemophilus influenzae 0.015 µg/mL – 1 µg/mL
    • Escherichia coli 0.015 µg/mL - 8 µg/mL
    • For a complete list of ceftibuten MIC values, click here.

Specifications

    Form

    Powder

    Appearance

    White to light yellow crystalline powder

    Source

    Synthetic

    Water Content (Karl Fisher)

    8.0-13.0%

    Optical Rotation

    +135° - +155°

    Assay

    90.0-102.0%

    Residue On Ignition

    ≤0.1%

    Heavy Metals

    ≤10 ppm

    Impurities

    Single Impurity: ≤1.0%
    Total Impurities: ≤2.0%

References

    References

    Georgopapadakou, N. H. "Mechanisms of Action of Cephalosporin 3'-quinolone Esters, Carbamates, and Tertiary Amines in Escherichia Coli." American Society for Microbiology 37.3 (1992): 559-65. Antimicrobial Agents and Chemotherapy. Web. 21 Aug. 2012.

Other Items In This Category