• Cefpodoxime sodium salt packaged and labeled.

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SKU: C096

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Description

Cefpodoxime Sodium is a broad-spectrum, third-generation cephalosporin β-lactam antibiotic that interferes with bacterial cell wall.  It is effective against a wide range of Gram-positive and Gram-negative bacteria.  Cefpodoxime Sodium is soluble in DMSO.

We also offer:

  •  Cefpodoxime Proxetil (C015)
  •  Cefpodoxime Free Acid (C016)

    CAS Number

    82619-04-3

    Molecular Formula

    C15H16N5NaO6S2

    Molecular Weight

    449.44

    Mechanism of Action

    Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases. However, like many cephalosporins, cefpodoxime is stable in the presence of β-lactamases.

    Storage Conditions

    -20°C. Protect from light.

    Tariff Code

    2941.90.5000

    Spectrum

    Cefpodoxime Sodium is a broad-spectrum antibiotic which targets a wide variety of Gram-positive and Gram-negative bacteria especially those which cause otitis media and pharyngitis.

Applications

    Microbiology Applications

    Cefpodoxime Sodium is commonly used in clinical in vitromicrobiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive and Gram-negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options. Representative MIC values include:

    • Klebsiella pneumoniae 8 µg/mL - 64 µg/mL
    • Haemophilus influenzae 0.032 µg/mL – 1 µg/mL
    • For a complete list of cefpodoxime MIC values, click here.

    Cefpodoxime from TOKU-E was used as a reference compound when characterizing the extended-spectrum AmpC (ESAC) B-lactamase enzymes (Lahiri et al, 2014).

    In vitro kinetic modeling can be used to study the pharmacokinetic-pharmacodynamic modelling of the antibacterial activity of cefpodoxime.  This approach has more detailed information than the MIC about he time course of efficacy (Liu et al, 2005).

Specifications

    Form

    powder

    Appearance

    brown crystalline powder

    Source

    synthetic

    Impurity Profile

    report single impurity

    Water Content (Karl Fischer)

    report results

    Assay

    (HPLC) Report results

References

    References

    Georgopapadakou NH (1992)  Mechanisms of action of cephalosporin 3'-quinolone esters, carbamates, and tertiary amines in Escherichia coli. Antimicrob. Agents. Chemother. 37(3):559-565

    Lahiri SD, Giacobbe RA, Johnstone MR and Alm RA (2014)  Activity of avibactam against Enterobacter cloacae producing an extended-spectrum class C β-lactamase enzyme. J. Antimicrob. Chemother. 69(11):2942–2946  PMID

    Liu P, Rand KH, Obermann B and Derendorf H (2005)  Pharmacokinetic-pharmacodynamic modelling of antibacterial activity of cefpodoxime and cefixime in in vitro kinetic models. Int. J. Antimicrob. Agents 25(2):120-129  PMID 15664481

    Wise R,  Andrews JM, Ashby JP and Thornber D (1990)  The in-vitro activity of cefpodoxime: a comparison with other oral cephalosporins.  J. Antimicrob. Chemother.  25(4):541–550  PMID 2351624

    Alm et al. used cefpodoxime from TOKU-E against Escherichia coli NDM isolates in microdilution MIC assays. "Characterization of Escherichia coli NDM isolates with decreased susceptibility to aztreonam/avibactam: role of a novel insertion in PBP3."

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