• Cefpirome sulfate w/ sodium carbonate packaged and labeled.

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SKU: C055

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Description

Cefpirome Sulfate solubilized is a mixture of Cefpirome Sulfate with anhydrous sodium carbonate that is used to stabilize the pH in aqueous solution.  Cefpirome Sulfate is commonly susceptible to degradation in aqueous solutions at pH range of 0.44 – 13 and this hydrolysis is a first-order reaction, with best stability at pH 4-6.  The addition of anhydrous sodium carbonate stabilizes the pH to slow the degradation in aqueous solutions.  Cefpirome Sulfate is a semisynthetic, broad-spectrum, fourth generation cephalosporin antibiotic that inhibits bacterial cell wall synthesis, and is resistant to β -lactamases.  Cefpirome Sulfate solubilized is soluble in water.

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  • Cefpirome Sulfate (C014)

    CAS Number

    98753-19-6 (Cefpirome Sulfate)

    Molecular Formula

    C22H22N6O5S2·H2SO4 (Cefpirome Sulfate)

    Molecular Weight

    612.66 (Cefpirome Sulfate)

    Mechanism of Action

    Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases.

    The relative lack of cross-resistance between Cefpirome and the third-generation cephalosporins suggests a slightly different mechanism of action of Cefpirome in comparison to the other cephalosporins.

    Due to its compact dipolar structure, Cefpirome can penetrate Gram-negative bacteria more quickly than the other agents (Nikaido et al, 1990).

    Storage Conditions

    -20°C

    Tariff Code

    2941.90.3000

    Spectrum

    Cefpirome is a broad-spectrum antibiotic targeting a wide variety of Gram-positive and Gram-negative bacteria. Many Bacteroides, Enterococci, and Haemophilus species have developed resistance to Cefpirome.

Applications

    Cancer Applications

    Cefpirome was found to be more effective than ceftazidime, aztreonam, timentin, and piperacillin against nosocomially important isolates from cancer patients during in vitro examination of 253 bacterial isolates (Rolston et al, 1986).

    Microbiology Applications

    Cefpirome Sulfate solubilized is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive and Gram-negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options . Representative effective ranges include:

    • Campylobacter jejuni 0.5 µg/mL – 8 µg/mL
    • Klebsiella pneumoniae 0.032 µg/mL – 0.125 µg/mL
    • Pseudomonas aeruginosa 2 µg/mL 32 µg/m
    • For a representative list of Cefpirome MIC values, click here.

Specifications

    Form

    Powder

    Appearance

    White or slightly yellow crystalline powder

    Source

    Mixture

    Impurity Profile

    Sodium Carbonate: 10.8 - 19.7%

    pH

    5.5-7.5

    Assay

    (On Dried Basis): 80.3-89.2% (content of cefpirome sulfate)

    Loss on Drying

    ≤3.0%

References

    References

    Hafeez S, Izhar M, Ahmed A, Zafar A, and Naeem M (2000) In vitro antimicrobial activity of Cefpirome: a new fourth-generation cephalosporin against clinically significant bacteria. J. Pak. Med. Assoc. 50(8):250-252 PMID 10992706

    Kobayashi S, Arai S, Hayashi S and Fujimoto K (1986) β-Lactamase Stability of Cefpirome (HR 810), a new cephalosporin with a broad antimicrobial spectrum. Antimicrob. Agents Chemother. 30(5):713-718 PMID 3492175

    Nikaido H, Liu W and Rosenberg EY (1990) Outer membrane permeability and beta-lactamase stability of dipolar ionic cephalosporins containing methoxyimino substituents. Antimicrob. Agents Chemother. 34(2):337-342 PMID 2109581

    Rolston KVI, Alvarez ME, Hsu K, and Bodey GP (1986) In-vitro activity of cefpirome (HR-810), WIN-49375, BMY-28142 and other antibiotics against nosocomially important isolates from cancer patients, J. Antimicrob. Chemother. 17(4):453–457

    Rolston K et al (1986) Comparative in vitro activity of cefpirome and other antimicrobial agents against isolates from cancer patients. Chemother. 32(4):344-351

    Zalewski P et al (2016)  Stability of Cefpirome Sulfate in aqueous solutions. Acta Poloneae Pharma- Drug Res. 73(1):23-27

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