• Cefditoren packaged and labeled.

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SKU: C100

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Description

Cefditoren is a third generation cephalosporin antibiotic.

TOKU-E offers three forms of cefditoren: cefditoren (C100), cefditoren sodium (C094), and cefditoren pivoxil (C050). Cefditoren sodium is soluble in aqueous solution, and cefditoren pivoxil is soluble in fat.

    CAS Number

    104145-95-1

    Molecular Formula

    C19H18N6O5S3

    Molecular Weight

    506.58 g/mol

    Mechanism of Action

    Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases.

    Tariff Code

    2941.90.5000

    Spectrum

    Cefditoren is a broad spectrum antibiotic commonly used against bacteria responsible for community acquired pneumonia and pharyngitis

Applications

    Microbiology Applications

    Cefditoren can be used to study antibiotic effects against group A Streptococcus and other microbes responsible for phayrngitis.

References

    References

    Poveda, J. L., et al. "Cefditoren Pivoxil: A New Oral Cephalosporin for Skin, Soft Tissue and Respiratory Tract Infections." Medline 19.3 (n.d.): 231-46.www.ncbi.gov. Web. 27 Aug. 2012.

    Georgopapadakou, N. H. "Mechanisms of Action of Cephalosporin 3'-quinolone Esters, Carbamates, and Tertiary Amines in Escherichia Coli." American Society for Microbiology 37.3 (1992): 559-65. Antimicrobial Agents and Chemotherapy. Web. 21 Aug. 2012.

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