• Cefdinir packaged and labeled.

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SKU: C049

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Description

Cefdinir is a broad spectrum third generation cephalosporin antibiotic resistant to many β-lactamase enzymes.  Cefdinir is highly soluble in aqueous solution (87.2 mg/mL).

Kaul et al. used cefdinir from TOKU-E to study synergistic effects of cefdinir and the prodrug, TXA709 against Methicillin-Resistant Staphylococcus aureus (MRSA)."Combining the FtsZ-Targeting Prodrug TXA709 and the Cephalosporin cefdinir confers synergy and reduces the frequency of resistance in Methicillin-resistant Staphylococcus aureus." 

    CAS Number

    91832-40-5

    Molecular Formula

    C14H13N5O5S2

    Molecular Weight

    395.42

    Mechanism of Action

    Cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases, however, cefdinir is not typically inactivated by this mechanism.

    Storage Conditions

    -20°C

    Tariff Code

    2941.90.5000

    Spectrum

    Cefdinir is a broad spectrum antibiotic targeting both gram positive and gram negative pathogens responsible for ear, sinus and skin infections.

Applications

    Microbiology Applications

    Cefdinir is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Haemophilus influenzae 0.05 µg/mL – 3.13 µg/mL
    • Staphylococcus aureus 0.125 µg/mL - >128 µg/mL
    • For a complete list of cefdinir MIC values, click here.

Specifications

    Form

    Powder

    Appearance

    White or light yellow powder

    Source

    Synthetic

    Water Content (Karl Fisher)

    ≤3.0%

    Optical Rotation

    -67° to -61°

    Assay

    (On Dried Basis): 960-1020 µg/mg

    Residue On Ignition

    ≤0.2%

    Impurities

    Impurity G: ≤0.7%
    Single Impurity: ≤0.2%
    Total Impurities: ≤3.0%

References

    References

    Georgopapadakou, N. H. "Mechanisms of Action of Cephalosporin 3'-quinolone Esters, Carbamates, and Tertiary Amines in Escherichia Coli." American Society for Microbiology 37.3 (1992): 559-65. Antimicrobial Agents and Chemotherapy. Web. 21 Aug. 2012.

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