• Cefamandole nafate packaged and labeled.

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SKU: C078

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Description

Cefamandole nafate is a second generation cephalosporin antibiotic.

TOKU-E offers two forms of cefamandole: cefamandole nafate (C078), and cefamandole sodium salt (C079). In aqueous solution, cefamandole nafate is freely soluble and sparingly soluble in methanol. Cefamandole sodium is freely soluble in an aqueous solution.

    CAS Number

    42540-40-9

    Molecular Formula

    C19H17N6NaO6S2

    Molecular Weight

    512.49

    Mechanism of Action

    Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases.

    Storage Conditions

    -20°C

    Tariff Code

    2941.90.3000

    Spectrum

    Cefamandole is a broad spectrum cephalosporin targeting a wide variety of gram positive and gram negative bacteria.

Applications

    Microbiology Applications

    Cefamandole nafate is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Escherichia coli 0.08 µg/mL – 100 µg/mL
    • Klebsiella pneumoniae 0.8 µg/mL – 12.5 µg/mL
    • For a complete list of cefamandole MIC values, click here.

Specifications

    Form

    Powder

    Appearance

    White or almost white powder

    Source

    Semi-synthetic

    Impurity Profile

    |Cefamandole nafate|42540-40-9|C19H17N6NaO6S2|512.5| |Cefamandole sodium|30034-03-8|C18H17NaO5S2|484.5| Impurity A| formylmandeloyl-7-amino-desacetoxy-cephalosporanic acid||C16H16N2O6S|364.4| Impurity C| O-acetylcefamandole||C18H20N6O6S2|480.5| Impurity D| 1-methyl-1H-tetrazole-5-thiol|69713-31-1|C2H4N4S|16.145| Impurity E| formylmandeloyl-7-ACA||C19H18N2O8S|434.4|

    Water Content (Karl Fischer)

    ≤2.0%

    pH

    3.5-7.0

    Assay

    (On Dried Basis): 810-1000µg/mg

References

    References

    Georgopapadakou, N. H. "Mechanisms of Action of Cephalosporin 3'-quinolone Esters, Carbamates, and Tertiary Amines in Escherichia Coli." American Society for Microbiology 37.3 (1992): 559-65. Antimicrobial Agents and Chemotherapy. Web. 21 Aug. 2012.

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