• Cefaclor, USP packaged and labeled.

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SKU: C005

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Description

Cefaclor is a second generation cephalosporin antibiotic derived from the Acremonium fungus. Cefaclor is slightly soluble in aqueous solution (8.6mg/mL).

    CAS Number

    70356-03-5

    Molecular Formula

    C15H14ClN3O4S • H2O

    Molecular Weight

    385.82

    Mechanism of Action

    Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases.

    Storage Conditions

    -20°C

    Tariff Code

    2941.90.3000

    Spectrum

    Cefaclor is a broad spectrum antibiotic commonly used against bacteria that cause pneumonia and meningitis such as Streptococcus pneumoniae and Haemophilus influenzae

Applications

    Microbiology Applications

    Cefaclor is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Streptococcus pneumoniae 0.25 µg/mL - >64 µg/mL
    • Haemophilus influenzae 0.25 µg/mL - >32 µg/mL
    • For a complete list of cefaclor MIC values, click here.

Specifications

    Form

    Powder

    Appearance

    White or off-white powder

    Source

    Semi-synthetic

    Water Content (Karl Fischer)

    3.0-6.5%

    pH

    3.0-4.5

    Assay

    (Anhdrous): 950-1020 µg/mg

    Impurities

    Individual impurities: ≤0.5%
    Total impurities: ≤2.0%

    Residual Solvents

    Methylene dichloride: Not more than 0.06%

References

    References

    Georgopapadakou, N. H. "Mechanisms of Action of Cephalosporin 3'-quinolone Esters, Carbamates, and Tertiary Amines in Escherichia Coli." American Society for Microbiology 37.3 (1992): 559-65. Antimicrobial Agents and Chemotherapy. Web. 21 Aug. 2012.

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