• Brefeldin A packaged and labeled.

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SKU: B012

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Description

Brefeldin A is a mammalian and plant cell antibiotic involved in protein transport inhibition and tumor apoptosis.

This product is considered a dangerous good. Quantities above 1 g may be subject to additional shipping fees. Please contact us for specific questions. 

    CAS Number

    20350-15-6

    Molecular Formula

    C16H24O4

    Molecular Weight

    280.36

    Mechanism of Action

    Brefeldin A inhibits protein transport by preventing accumulation of COPI proteins on the Golgi apparatus which facilitate vesicle fusion from the endoplasmic reticulum (ER). By preventing Golgi-COPI protein function, vesicles from the ER cannot properly fuse with the Golgi to be secreted to destined locations.

    Storage Conditions

    2-8°C

    Tariff Code

    2941.90.1050

Applications

    Cancer Applications

    Brefeldin A has demonstrated anti-cancer properties by inducing apoptosis in leukemia and colon carcinoma cells.

Specifications

    Form

    Powder

    Appearance

    White or almost white powder

    Source

    Penicillium brefeldianum

Technical Data

HPLC Chromatogram Showing Ultra High, Single Fraction Purity of Brefeldin A, EvoPure®

Brefeldin A HPLC

 

 Mass Spectrometry Results of Brefeldin A

Brefeldin A Mass Spec

References

    References

    Nebenführ, Andreas, et al. "Brefeldin A: Deciphering an Enigmatic Inhibitor of Secretion." American Society of Plant Biologists 130.3 (2002): 1102-108. Plantphysiol.org. Nov. 2002. Web. 29 Oct. 2012.

    Shao, R. G. "Brefeldin A Is a Potent Inducer of Apoptosis in Human Cancer Cells Independently of P53." Experimental Cell Research 15.227 (1996): 190-96. Ncbi.gov. Web. 18 Sept. 2012.

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