• Azithromycin dihydrate packaged and labeled.

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SKU: A024

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Description

Azithromycin dihydrate is a broad spectrum macrolide antibiotic structurally related to erythromycin.  Azithromycin dihydrate is sparingly soluble in aqueous solution (0.54 mg/mL).

    CAS Number

    117772-70-0

    Molecular Formula

    C38H72N2O12•2H2O

    Molecular Weight

    785.01

    Mechanism of Action

    Macrolide antibiotics inhibit bacterial growth by targeting the 50S ribosomal subunit preventing peptide bond formation and translocation during protein synthesis. Resistance to azithromycin is commonly attributed to mutations in 50S rRNA preventing azithromycin binding allowing the cell to synthesize proteins free of error.

    Storage Conditions

    ≤30°C

    Tariff Code

    2941.50.0000

    Spectrum

    Several members of gram positive and gram negative bacteria as well as certain mycoplasma species are susceptible to azithromycin.

Applications

    Microbiology Applications

    Azithromycin dihydrate is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Chlamydia trachomatis 0.016 µg/mL-0.125 µg/mL
    • Mycobacterium avium 16 µg/mL- >256 µg/mL
    • For a complete list of azithromycin MIC values, click here.

Specifications

    Form

    Powder

    Appearance

    White crystalline powder

    Source

    Semi-synthetic

    Water Content (Karl Fisher)

    4.0-5.0%

    pH

    9.0 - 11.0

    Optical Rotation

    -45° to -49º

    Assay

    (On Dried Basi): 945-1030 µg/mg

    Residue On Ignition

    ≤0.3%

    Heavy Metals

    ≤25ppm

References

    References

    Lovmar, Martin, and Tanel Tenson. "The Mechanism of Action of Macrolides, Lincosamides and Streptogramin B Reveals the Nascent Peptide Exit Path in the Ribosome."Journal of Molecular Microbiology 330.5 (2003): 1005-014.

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