• Azithromycin dihydrate packaged and labeled.

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SKU: A024

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Description

Azithromycin dihydrate is a broad-spectrum macrolide antibiotic (azalide subclass) derived from Erythromycin.  It is effective against many Gram-negative and Gram-positive bacteria and certain Mycoplasma species.   Azithromycin also has anti-immunomodulatory/anti-inflammatory properties.  Azithromycin dihydrate is sparingly soluble in aqueous solution (0.54 mg/mL).

We also offer the following derivatives:

    CAS Number

    117772-70-0 9 (dihydrate); 83905-01-5 (anhydrous); 121479-24-4 (monohydrate)

    Molecular Formula

    C38H72N2O12•2H2O

    Molecular Weight

    785.01

    Mechanism of Action

    Macrolide antibiotics inhibit bacterial growth by binding to the 70S ribosome (specifically the 50S subunit) preventing peptide bond formation and translocation during protein synthesis. Resistance is attributed to mutations in 50S rRNA preventing binding of Azithromycin and allowing the cell to synthesize error-free proteins.

    Storage Conditions

    ≤30°C

    Tariff Code

    2941.50.0000

    Spectrum

    Azithromycin is effective against several Gram-positive and Gram-negative bacteria, and certain Mycoplasmas.

Applications

    Microbiology Applications

    Azithromycin dihydrate is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive and Gram-negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Chlamydia trachomatis 0.016 µg/mL-0.125 µg/mL
    • Mycobacterium avium 16 µg/mL- >256 µg/mL
    • For a complete list of azithromycin MIC values, click here.

Specifications

    Form

    Powder

    Appearance

    White crystalline powder

    Source

    Semi-synthetic

    Water Content (Karl Fischer)

    4.0-5.0%

    pH

    9.0 - 11.0

    Optical Rotation

    -45° to -49º

    Assay

    (On Dried Basi): 945-1030 µg/mg

    Residue On Ignition

    ≤0.3%

    Heavy Metals

    ≤25ppm

References

    References

    Gladue RP, Bright GM, Isaacson RE and Newborg MF (1989) In vitro and in vivo uptake of Azithromycin (CP-62,993) by phagocytic cells: Possible mechanism of delivery and release at sites of infection. Antimicrob. Agents Chemother. 33(3):277-282 PMID 2543276

    Lovmar, M, and Tenson T (2003) The Mechanism of action of Macrolides, Lincosamides and Streptomycin B reveals the nascent peptide exit path in the ribosome. J. Mol. Microbiol. 330(5):1005-1014. PMID 10348778

    Wolf K and Malinverni R (1999) Effect of Azithromycin plus Rifampin versus that of Zithromycin alone on the eradication of Chlamydia pneumoniae from lung tissue in experimental pneumonitis. Antimicrob. Agents Chemother. 43(6): 1491-3 PMID 10348778

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