• Acriflavine hydrochloride packaged and labeled in glass bottle.

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SKU: A019

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Description

Acriflavine HCl is a type of dye commonly used as a topical antiseptic for skin infections. Acriflavine is freely soluble in aqueous solution.

This product is considered a dangerous good. Quantities above 1 g may be subject to additional shipping fees. Please contact us for specific questions.

    CAS Number

    8063-24-9

    Molecular Formula

    C13H11N3 and C14H14N3 •HCl

    Molecular Weight

    209.172 and 260.75

    Mechanism of Action

    Acriflavine toxicity arises from its ability to bind to and intercalate DNA. DNA intercalation leads to numerous errors which have a lethal effect on targeted organisms.

    Storage Conditions

    2-8 °C

    Tariff Code

    2941.20.5000

Applications

    Cancer Applications

    Acriflavine has been shown to inhibit HIF-1, a heterodimeric transcription factor which responds to hypoxia and facilitates further cancer progress. Acriflavine prevents dimerization of HIF-1 to prevent its role in cancer growth.

    Microbiology Applications

    Acriflavine has been used in RNA fluorescent labeling applications by RNA hydrolysis using HCl.

Specifications

    Form

    Powder

    Appearance

    Brown or orange powder

    Assay

    (Dried Basis): 98.5-107.0%

    Loss on Drying

    ≤7.0%

    Residue On Ignition

    ≤0.5%

    Heavy Metals

    Arsenic (As): ≤0.001%

References

    References

    Kawai, Mako, and Et Al. "Mechanisms of Action of Acriflavine: Electron Microscopic Study of Cell Wall Changes Induced in Staphylococcus Aureus by Acriflavine."Microbiology and Immunology (2009): 481-86. Onlinelibrary.com. Web. 29 Aug. 2012.

    Levinson, J. W. "Fluorescent Labeling of Fragments of High Molecular Weight RNA." Energy Citations. N.p., n.d. Web. 18 Sept. 2012.

    Lee, K., and Et Al. "Acriflavine Inhibits HIF-1 Dimerization, Tumor Growth, and Vascularization." Proceedings of the National Academy of Sciences of the United States of America 106.42 (2009): 17910-7915. Pnas.org. 20 Oct. 2009. Web. 20 Sept. 2012.

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