Acriflavine hydrochloride

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Acriflavine hydrochloride

SKU: A019

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Description

Acriflavine HCl is a type of dye commonly used as a topical antiseptic for skin infections. Acriflavine is freely soluble in aqueous solution.

This product is considered a dangerous good. Quantities above 1 g may be subject to additional shipping fees. Please contact us for specific questions.

CAS Number

8063-24-9

Molecular Formula

C₁₃H₁₁N₃ and C₁₄H₁₄N₃ •HCl

Molecular Weight

209.172 and 260.75

Mechanism of Action

Acriflavine toxicity arises from its ability to bind to and intercalate DNA. DNA intercalation leads to numerous errors which have a lethal effect on targeted organisms.

Storage Conditions

2-8 °C

Tariff Code

2941.20.5000

Applications

Cancer Applications

Acriflavine has been shown to inhibit HIF-1, a heterodimeric transcription factor which responds to hypoxia and facilitates further cancer progress. Acriflavine prevents dimerization of HIF-1 to prevent its role in cancer growth.

Microbiology Applications

Acriflavine has been used in RNA fluorescent labeling applications by RNA hydrolysis using HCl.

Specifications

Form

Powder

Appearance

Brown or orange powder

Assay

(Dried Basis): 98.5-107.0%

Loss on Drying

≤7.0%

Residue On Ignition

≤0.5%

Heavy Metals

Arsenic (As): ≤0.001%

Technical Data

References

Kawai, Mako, and Et Al. "Mechanisms of Action of Acriﬂavine: Electron Microscopic Study of Cell Wall Changes Induced in Staphylococcus Aureus by Acriﬂavine."Microbiology and Immunology (2009): 481-86. Onlinelibrary.com. Web. 29 Aug. 2012.

Levinson, J. W. "Fluorescent Labeling of Fragments of High Molecular Weight RNA." Energy Citations. N.p., n.d. Web. 18 Sept. 2012.

Lee, K., and Et Al. "Acriflavine Inhibits HIF-1 Dimerization, Tumor Growth, and Vascularization." Proceedings of the National Academy of Sciences of the United States of America 106.42 (2009): 17910-7915. Pnas.org. 20 Oct. 2009. Web. 20 Sept. 2012.