SKU: V030

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Description

Virginiamycin is a streptogramin, and a mixture of Virginiamycin M1 and Virginiamycin S1.  The commercial mixture is 75 % Virginiamycin M1 and 25 % Virginiamycin S1, along with less abundant S analogs.  The mixture can be used to reduce contaminating bacteria during yeast fermentation for bioethanol production.  Virginiamycin is soluble in DMSO and DMF.

    CAS Number

    11006-76-1

    Molecular Formula

    C28H35N3O7 (for M1), C43H49N7O10 (for S1)

    Molecular Weight

    525.6 (for M1); 823.9 (for S1)

    Mechanism of Action

    Virginiamycin inhibits protein synthesis, targeting the 50S ribosome and inducing a conformational change at the peptidyl transferase center. Protein synthesis is inhibited in both actively growing and static bacterial cells.

    Storage Conditions

    -20C

    Spectrum

    Gram-positive bacteria, such as Lactobacillus spp.

Applications

    Microbiology Applications

    Virginiamycin is used in bioproduction, specifically to reduce contaminating bacteria when fermenting yeast for bioethanol production.

Specifications

    Form

    Solid

    Appearance

    White solid

    Source

    Streptomyces virginiae

References

    References

    Bischoff KM, Liu S, Leathers TD, Worthington RE and Rich JO (2008) Modeling bacterial contamination of fuel ethanol fermentation. Biotechnol. Bioeng. 103(1):117-122 Crooy P and De Neys RJ (1972) Virginiamycin: nomenclature. Antibiot. 25:371 Ogata K et al (1978) A new species of Streptomyces producing virginiamycin family antibiotics. J. Antibiot. 31: 1313 Parfait R and Cocito C (1980) Lasting damage to bacterial ribosomes by reversibly bound virginiamycin M. Proc. Natl. Acad. Sci. USA 77(9):5492-5496 Rich JO et al (2011) Rapid evaluation of the antibiotic susceptibility of fuel ethanol contaminant biofilms. Bioresour. Technol. 102 (2):1124-1130

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