• Vancomycin HCl, USP packaged and labeled.

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SKU: V001

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Description

Vancomycin HCl, USP is a bactericidal glycopeptide antibiotic and has been used to treat infections caused by multi drug resistant bacteria including methicillin resistant Staphylococcus aureus (MRSA).

Vancomycin HCl, USP is freely soluble in water. Click here for more vancomycin products.

    CAS Number

    1404-93-9

    Molecular Formula

    C66H75Cl2N9O24 · HCl

    Molecular Weight

    1485.71

    Mechanism of Action

    Vancomycin prevents peptidoglycan synthesis by two separate mechanisms. One mechanism prevents N-acetylmuramic acid (NAM) and N-acetylglucosamine (NAG) from linking together forming the peptidoglycan backbone. The second mechanism prevents crosslinking between amino acid residues in the peptidoglycan chain.

    Storage Conditions

    2-8°C, protect from light

    Tariff Code

    2941.90.5000

    Spectrum

    Vancomycin inhibits growth of many Gram positive bacteria including the antibiotic resistant superbug, MRSA (Methicillin resistant Staphylococcus aureus). Vancomcyin is effective for treating MRSA infections because it inhibits cell wall synthesis through a different mechanism than β-lactam antibiotics.

Applications
Specifications

    Form

    Powder

    Appearance

    White or light brown powder

    Source

    Streptomyces orientalis

    Impurity Profile

    Vancomycin B: Not less than 85%
    Any Individual Impurity: Not more than 5.0%

    Water Content (Karl Fisher)

    Not more than 5.0%

    pH

    2.5 - 4.5

    Assay

    (Dried Basis): Not less than 900 μg/mg

References

    References

    Courvalin, Patrice. "Vancomycin Resistance in Gram-Positive Cocci." Oxford Journals(2006): 25-34. Clinical Infectious Diseaes. Web. 21 Aug. 2012.

    Pollock, H.M., Holt J., and Murray C., Comparison of susceptibilities of anaerobic bacteria to cefemenoxime, ceftriaxone and other antimicrobial compounds, Antimicrob. Agents Chemother., Vol. 23, pp.780-783, 1983

    Silva J.A. and Fukai S., The impact of carbenicillin, cefotaxime and vancomycin on chrysanthemum and tobacco TCL morphogenesis and Agrobacterium growth, J. Appl. Hort., Vol. 3(1), pp. 3-12, 2001.

    Joshi, S., Ray, P., Manchanda, V., Bajaj, J., Chitnis, D. S., Gautam, V., &...Balaji, V. (2013). Methicillin resistant Staphylococcus aureus (MRSA) in India: Prevalence & susceptibility pattern. Indian Journal Of Medical Research, 137(2), 363-369

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