SKU: V026

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Description
Valrubicin is a semisynthetic derivative of the antineoplastic anthracycline antibiotic doxorubicin  It is used to treat  bladder cancer

    CAS Number

    56124-62-0

    Molecular Formula

    C34H36F3NO13

    Molecular Weight

    723.65

    Mechanism of Action

    Valrubicin is converted into N-trifluoroacetyladriamycin, which interacts with topoisomerase II, an enzyme that relaxes DNA supercoils. DNA replication and repair is inhibited, which prevents RNA synthesis and protein production, resulting in cell cycle arrest in phase G2. Valrubicin also accumulates in the cytoplasm where it inhibits protein kinase C.

    Storage Conditions

    ≤30°C (avoid light)

Specifications

    Form

    Powder

    Appearance

    Orange to orange red crystalline powder

    Source

    Synthetic

References

    References

    Onrust CV and Lamb HM (1999). Valrubicin. Drugs Aging 15:69-75 Sabnis N et al (2012) Enhanced solubility and functionality of valrubicin (AD-32) against cancer cells upon encapsulation into biocompatible nanoparticles. Int J Nanomedicine 7:975-983

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