SKU: T118

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Description
Tedizolid Phosphate is an oxazolidone antibiotic.  It is a phosphate ester prodrug of Tedizolid, the active compound.  It is bacteriostatic against Gram-positive organisms.

    CAS Number

    856867-55-5

    Molecular Formula

    C17H16FN6O6P

    Molecular Weight

    450.32 g/mol

    Mechanism of Action

    Tedizolid binds to the 23S rRNA of the 50S ribosomal subunit, preventing the formation of the 70S initiation complex and inhibiting protein synthesis.

    Storage Conditions

    -20C

    Spectrum

    Effective against Gram-positive bacteria including MRSA and VRE, and linezolid-resistant strains

Applications

    Microbiology Applications

    Tedizolid inhibited all 28 isolates of penicillin-resistant Streptococcus pneumoniae using an in vitro mouse model with 0.25 µg/mL, which was 4-fold more potent than Linezolid (Choi et al, 2012).

Specifications

    Form

    Powder

    Appearance

    White to off-white powder

    Source

    Synthetic

References

    References

    Choi S, Im W, and Bartizal K (2012) Activity of tedizolid phosphate (TR-701) in murine models of infection with penicillin-resistant and penicillin-sensitive Streptococcus pneumoniae. Antimicrob Agents Chemother. 2012 Sep;56(9):4713-7 PMID 22713339 Kisgen JJ, Mansour H, Unger NR, Childs LM (2014) Tedizolid: a new oxazolidinone antimicrobial. Am. J. Health Syst. Pharm. 71(8):621-33 PMID 24688035 Rybak JM, Marx K, Martin CA (2014) Early experience with tedizolid: Clinical efficacy, pharmacodynamics, and resistance. Pharmacother. 34(11):1198-208 PMID 25266820

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