SKU: R045

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Description
Rocuronium bromide is an aminosteroid non-depolarizing neuromuscular blocker that relaxes the skeletal muscle.  It was introduced in 1994, and has a similar pharmacokinetic profile to Vecuronium.

    CAS Number

    119302-91-9

    Molecular Formula

    C32H53BrN2O4

    Molecular Weight

    609.68

    Mechanism of Action

    Rocuronium Bromide competes with acetylcholine and binds to cholinergic receptors at neuromuscular junctions. It binds to nicotinic receptors in the neuromuscular junction.

    Storage Conditions

    ≤30°C

    Tariff Code

    2934.99.4700

Applications

    Eukaryotic Cell Culture Applications

    The human peripheral blood lymphocytes were exposed to Rocuronium Bromide (60, 80 and 100 μg/mL). Findings from this study suggest that Rocuronium Bromide is clastogenic but not cytotoxic to cultured human peripheral blood lymphocytes (Zan et al, 2011).

Specifications

    Form

    Powder

    Appearance

    off-white to yellowish powder

    Source

    Synthetic

References

    References

    Koksal PM and Gürbüzel M(2015) Analysis of genotoxic activity of ketamine and rocuronium bromide using the somatic mutation and recombination test in Drosophila melanogaster. Environ Toxicol Pharmacol. 39(2):628-634 Sauer et al (2017) Rocuronium is more hepatotoxic than succinylcholine in vitro. Eur. J. Anaesthesiol 34(9):623-627 PMID 28763317 Zan U, Topaktas M, Istifli EA (2011) In vitro genotoxicity of rocuronium bromide in human peripheral lymphocytes. Cytotechnol. 63(3):239-245

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