SKU: Q013

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Description

Quetiapine Fumarate is an inhibitor of dopamine and serotonin. Serotonin is a neurotransmitter thought to play a role in depression and schizophrenia.

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    CAS Number

    111974-72-2

    Molecular Formula

    C21H25N3O2S · 0.5C4H4O4

    Molecular Weight

    441.54

    Mechanism of Action

    Quetiapine Fumarate is a dibenzothiazepine with antagonist activity at dopamine (D1, D2, D3) and serotonin (5-HT1A and 5-HT2) receptors. It also antagonizes adrenoreceptors (alpha 1A, alpha 1b, alpha 2) and histamine receptor (H1).

    Storage Conditions

    2-8C

    Tariff Code

    2934.99.3000

Applications

    Eukaryotic Cell Culture Applications

    Quetiapine was found to alleviate oxidative stress in PC12 cells, leading to higher cell viability and a lower rate of apoptosis. These studies give new insight into the link between oxidative stress and pathophysiology of schizophrenia and Alzheimer's (Wang et al, 2005).

Specifications

    Form

    Powder

    Appearance

    White to off-white powder

    Source

    Synthetic

References

    References

    Richelson E and Souder T (2000) Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci.68(1):29-39 PMID 11132243 Wetzel H et al (1995) Seroquel (ICI 204 636), a putative "atypical" antipsychotic, in szhizophrenia with positive symptomatology: Results of an open clinical trial and changes of neuroendocrinological and EEG parameters. Phychopharmacol 119(2):231-238 PMID 7659771 Wang H et al (2005) Olanzapine and quetiapine protect PC12 cells from B-amyloid peptide25-35-induced oxidative stress and the ensuring apoptosis. J. Neurosci. Res. 81(4):572-580

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