SKU: O040

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Description

Oxiracetam is nootropic agent of the racetam family, a very mild stimulant that has been shown to improve memory and learning. It is a
derivative of γ-aminobutyric acid (GABA,) the chief inhibitory neurotransmitter in mammals.

    CAS Number

    62613-82-5

    Molecular Formula

    C6H10N2O3

    Molecular Weight

    158.157

    Mechanism of Action

    The mechanism of action of Oxirectam is not yet known, but it may modulate glutamatergic neurotransmission. In mice, it interacts with the glutamatergic NMDA receptor system, forestalling the impairment of retrieval of long-term memory.

    Storage Conditions

    2-8°C

Applications

    Eukaryotic Cell Culture Applications

    Oxiracetam enhanced α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid (AMPA)‐stimulated 45Ca2+ influx in primary cultures of cerebellar granule cells. The nootropic agent ncreased the maximal density of the specific binding sites for [3H]AMPA in synaptic membranes from rat cerebral cortex. Results support the view that Oxiracetam and other nootropic agents act as positive modulators of AMPA‐sensitive glutamate receptors in neurons (Copani et al, 1992)

Specifications

    Form

    Powder

    Appearance

    white crystalline powder

    Source

    Synthetic

References

    References

    Copani A et al (1992) Nootropic Drugs Positively Modulate alpha‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid‐sensitive glutamate receptors in neuronal cultures. J. Neurochem. 58(4):1199-1204 PMID 1372342 Hlinák Z and Krejcí I (2000) Oxiracetam prevents the MK-801 induced amnesia for the elevated plus-maze in mice. Behav Brain Res. 117(1-2):147-151 PMID 11099768

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