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Oxiracetam is nootropic agent of the racetam family, a very mild stimulant that has been shown to improve memory and learning. It is a cyclic derivative of γ-aminobutyric acid (GABA,) the chief inhibitory neurotransmitter in mammals.  In pharma, it is used as a racemic mixture of (S)-oxiracetam and (R)-oxiracetam, the pharmacological activity is mainly associated with one enantiomer.  Oxiracetam is slightly soluble in water and DMSO but practically insoluble in ethanol.

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    Mechanism of Action

    The mechanism of action of Oxirectam is not yet known, but it may modulate glutamatergic neurotransmission. In mice, it interacts with the glutamatergic NMDA receptor system, forestalling the impairment of retrieval of long-term memory.

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    Eukaryotic Cell Culture Applications

    Oxiracetam enhanced α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid (AMPA)‐stimulated 45Ca2+ influx in primary cultures of cerebellar granule cells. The nootropic agent ncreased the maximal density of the specific binding sites for [3H]AMPA in synaptic membranes from rat cerebral cortex. Results support the view that Oxiracetam and other nootropic agents act as positive modulators of AMPA‐sensitive glutamate receptors in neurons (Copani et al, 1992).

    Authors found that it was (S)-oxiracetam that alleviated impairments in learning and memory, in the two vessel occlusion model (2-VO), a rat model used for chronic cerebral hypoperfusion.  It is thought that vascular dementia is associated with chronic cerebral hypoperfusion.  Using MALDI-MSI, authors explored the spatial distribution changes in small molecules  including ATP.  (S)-oxiracetam caused a reduction in the abnormal accumulation of glucose and citric acid in the brain and increase ATP metabolism.  It was also found for the first time to increase the Glutamate-glutamine cycle, malate-aspartate shuttle, and content of antioxidants and maintained homeostasis of Na+ and K+ in the rat cortex (Li et al, 2017).





    white crystalline powder





    Copani A et al (1992) Nootropic Drugs Positively Modulate alpha‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid‐sensitive glutamate receptors in neuronal cultures. J. Neurochem. 58(4):1199-1204 PMID 1372342

    Hlinák Z and Krejcí I (2000) Oxiracetam prevents the MK-801 induced amnesia for the elevated plus-maze in mice. Behav Brain Res. 117(1-2):147-151 PMID 11099768

    Li W et al (2017)  (S)-Oxiracetam is the active ingredient in Oxiracetam that alleviates the cognitive impairment induced by chronic cerebral hypoperfusion in rats. Sci. Rep. 7(1):10052  PMID 28855592

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