• Norfloxacin packaged and labeled.

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SKU: N008

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Description

Norfloxacin is a first generation synthetic fluoroquinolone antibiotic and is sparingly soluble in aqueous solution at 1mg/mL.

    CAS Number

    70458-96-7

    Molecular Formula

    C16H18FN3O3

    Molecular Weight

    319.33

    Mechanism of Action

    Norfloxacin indirectly inhibits DNA gyrase by binding to nearby DNA substrate. DNA gyrase is an essential DNA replication enzyme which reduces DNA strain during active DNA replication. Norfloxacin is most active in the pH range between 4.5 and 6.5.

    Storage Conditions

    2-8°C

    Tariff Code

    2933.59.3600

    Spectrum

    Norfloxacin is a broad spectrum antibiotic commonly used to target bacteria responsible for urinary tract infections.

Applications

    Microbiology Applications

    Norfloxacin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Escherichia coli 0.25 µg/mL – 10 µg/mL
    • For a complete list of norfloxacin MIC values, click here.

    Media Supplements

    Norfloxacin can be used as a selective agent in several types of isolation media:

    Clostridium difficile Agar - CDMN Selective Supplement

Specifications

    Form

    Powder

    Appearance

    White to light-yellow crystalline powder

    Source

    Synthetic

    Impurity Profile

    Heavy Metals: ≥0.0015%

    Melting Point

    220-221°C

    Assay

    (On Dried Basis): 99.0-101.0%

    Loss on Drying

    ≤1.0%

References

    References

    Wolfson, John S., and David C. Hooper. "The Fluoroquinolones: Structures, Mechanisms of Action and Resistance, and Spectra of Activity in Vitro." American Society for Microbiology 4th ser. 28 (1985): 581-86.

    Shen, Linus L., and Andre G. Pernet. "Mechanism of Inhibition of DNA Gyrase by Analogues of Nalidixic Acid: The Target of the Drugs Is DNA." PNAS 82 (1985): 307-11. Pnas.org. Web. 4 June 2013.

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