SKU: N062

Size  
Quantity:
 
Price: make selection(s)
Description
Nadifloxacin is a fluorinated fluoroquinolone antibiotic with broad-spectrum activity against Gram-positive and Gram-negative bacteria, especially Propionibacterium acnes.  It also shows antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA).  Nadifloxacin is capable of treating green nail syndrome caused by Pseudomonas aeruginosa.

    CAS Number

    124858-35-1

    Molecular Formula

    C19H21FN2O4

    Molecular Weight

    360.379 g/mol

    Mechanism of Action

    Nadifloxacin inhibits Topo II (DNA gyrase) in Gram-negative bacteria, and Topo IV in Gram-positive bacteria, which both function to relax positive supercoils prior to DNA replication, thus inhibiting bacterial multiplication.

    Storage Conditions

    -20°C

    Spectrum

    broad-spectrum activity against Gram-positive and Gram-negative bacteria.

Specifications

    Form

    Powder

    Appearance

    Off white to pale yellow crystalline powder

    Source

    Synthetic

References

    References

    Narayanan V et al (2014) Efficacy and safety of nadifloxacin for bacterial skin infections: Results from clinical and post-marketing studies. Dermatol. Ther. 4:233-248 Müller S (2014) Green nail syndrome (Pseudomonas aeruginosa nail infection): Two cases successfully treated with topical Nadifloxacin, an acne medication. Case Rep. Dermatol. 6:180-184.

Other Items In This Category