SKU: M093

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Description

MycoRid™ Solution (1000x) is a highly stable, solubilized aqueous solution of a polyene antifungal or antimycotic compound derived from the fermentation.

    Mechanism of Action

    The active component of MycoRid™ Solution (1000x) has a similar mode of action to Amphotericin B (fungizone). Polyene antimicrobials associate with membrane sterols in mammalian and fungal cell membranes and forms pores leading to essential ion leakage and ultimately, cell death.

    Storage Conditions

    -20°C

    Spectrum

    MycoRid™ Solution (1000x) is active against fungal (molds and yeasts) cells and is not toxic to bacteria due to their lack of sterols. MycoRid™ is compatible with Pen-Strep solutions.

Applications

    Microbiology Applications

    MycoRid™ Solution (1000x) is used as an antimycotic selective agent in several routinely used selective media formulations to inhibit the growth of background fungal growth.

Specifications

    Form

    Liquid

    Appearance

    Light Yellow Solution

    Source

    Fermentation

References

    References

    Rice, Louis B., and Mahmoud A. Ghannoum. "Antifungal Agents: Mode of Action, Mechanisms of Resistance, and Correlation of These Mechanisms with Bacterial Resistance." Clinical Microbiology Reviews (1999): 501-17. www.ncbi.gov. Oct. 1999. Web. 22 Aug. 2012.

    Rice L.B. and Ghannoum M.A.. "Antifungal Agents: Mode of Action, Mechanisms of Resistance, and Correlation of These Mechanisms with Bacterial Resistance. Clinical Microbiology Reviews (1999): 501-17.

    Brajtburg, J., W. G. Powderly, and G. Medoff. "Amphotericin B: Current Understanding of Mechanisms of Action." Antimicrobial Agents and Chemotherapy 34.2 (1990): 183-88. www.ncbi.gov. Web. 22 Aug. 2012.

    Perez-de-Luque A., Cifuentes Z., Beckstead J.A., Sillero J.C., Avila C., Rubio J. and Ryan R.O.. Effect of amphotericin B nanodisks on plant fungal diseases. Volume 68, Issue 1, Article first published online: 24 Jun 2011.

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