SKU: F043

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Description
Fosfomycin tromethamine is a phosphonic acid bactericidal agent with in vitro activity against most urinary tract pathogens.  It is active against E. coli, Citrobacter, Enterobacter, Klebsiella, Serratia and Enterococcus.  

    CAS Number

    78964-85-9

    Molecular Formula

    C7H18NO7P

    Molecular Weight

    259.19 g/mol

    Mechanism of Action

    Fosfomycin tromethamine inhibits bacterial cell (peptidoglycan) synthesis. Specifically, it inhibits enolpyruvyl transferase, thereby blocking the condensation of uridine diphosphate-N-acetylglucosamine, one of the first steps in peptidoglycan synthesis.

    Storage Conditions

    2-8°C, airtight, protect from light

    Tariff Code

    2941.90.9000

    Spectrum

    Broad spectrum against both Gram-positive and Gram-negative pathogens

Specifications

    Form

    Powder

    Appearance

    White or almost white powder

    Source

    Streptomyces fradiae

References

    References

    de Cueto M et al (2006) In vitro activity of Fosfomycin against extended-spectrum—lactamase producing Escherichia coli and Klebsiella pneumoniae: Comparison of susceptibility testing procedures. Antimicrobial. Agents and Chemother 50:368-370 Grif K et al (2001) In vitro activity of Fosfomycin in combination with various antistaphylococcal substances. J Antimicrob. Chemother 48:209-217 Kahan FM et al (1974) The mechanism of action of Fosfomycin (phosphonomycin) Ann. NY Acad Sci 235:364-386

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