SKU: E045

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Description

Etamsylate is a haemostatic agent, used to arrest blood flow at the capillary level. It has antihemorrhagic properties. The compound is soluble in water.

 

    CAS Number

    2624-44-4

    Molecular Formula

    C10H17NO5S

    Molecular Weight

    263.31

    Mechanism of Action

    Etamsylate acts on the first step of hemostasis by improving platelet adhesiveness and restoring capillary resistance. Recent studies showed that Ethamsylate promotes P-selectin-dependent, platelet adhesive mechanisms.

    Storage Conditions

    2-8┬░C

    Tariff Code

    2921.19.1100

Applications

    Eukaryotic Cell Culture Applications

    Researchers measured the expression of P-selectin in the membrane of SV40-transformed aortic rat endothelial cells. There was a significant increase in the percentage of platelets expressing P-selectin even at the lowest concentration (1 uM), with maximal enhancement at 10 uM (Alvarez-Guerra M et al, 2002).

Specifications

    Form

    crystalline powder

    Appearance

    white to almost white crystalline powder

    Source

    synthetic

References

    References

    Alvarez-Guerra M et al (2002) The hemostatic agent ethamsylate enhances P-selectin membrane expression in human platelets and cultured endothelial cells. Thromb. Res. 107(6):329-335 PMID 12565720 Garay RP, Chiavaroli C, and Hannaert P (2006) Therapeutic efficacy and mechanism of action of ethamsylate, a long-standing hemostatic agent. Am J Ther. 13(3):236-247 PMID 16772766