• 17-AAG packaged and labeled in glass bottle.

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SKU: A061

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Description

17-AAG (17-N-Allylamino-17-demethoxygeldanamycin) is a geldanamycin derived anti-tumor agent currently studied in cancer research.

    CAS Number

    75747-14-7

    Molecular Formula

    C31H43N3O8

    Molecular Weight

    585.69

    Mechanism of Action

    17-AAG targets and inactivates Hsp90 (heat shock protein 90), which is expressed in certain types of leukimia and lymphomas as well as solid tumors.

    Storage Conditions

    -20 ┬░C

    Tariff Code

    2941.90.5000

Applications

    Cancer Applications

    17-AAG has been shown to induce cell-cycle arrest and apoptosis in cultured ALCL cells irrespective of ALK expression. In addition, 17-AAG has shown promising results in the treatment of uveal melanoma through inhibition of HSP-90 in tandem with c-Kit inhibition.

Specifications

    Form

    Powder

    Appearance

    Purple powder

    Source

    Synthetic

References

    References

    Hawkins LM, Jayanthan AA, Narendran A., Effects of 17-allylamino-17-demethoxygeldanamycin (17-AAG) on pediatric acute lymphoblastic leukemia (ALL) with respect to Bcr-Abl status and imatinib mesylate sensitivity. Pediatr Res. 2005 Mar;57(3):430-7. Epub 2005 Jan 19

    Radujkovic A, Schad M, Topaly J, Veldwijk MR, Laufs S, Schultheis BS, Jauch A, Melo JV, Fruehauf S, Zeller WJ., Synergistic activity of imatinib and 17-AAG in imatinib-resistant CML cells overexpressing BCR-ABL--Inhibition of P-glycoprotein function by 17-AAG. Leukemia. 2005 Jul;19(7):1198-206.

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