Cancer Applications

10-Deacetyl Baccatin III is commonly used as an intermediate in the synthesis of paclitaxel (Taxol), an anti-cancer drug.

Plant Biology Applications

Taxus cell culture may be an alternate source of Paclitaxel, and significantly increased amounts of Paclitaxel were observed after exposure to methyl jasmonate (Yukimune et al, 1996).

Form

Powder

Appearance

White or off-White Powder

Source

Taxus Baccata

Loss on Drying

≤3.0%

References

Gelderblom H et al (1999)  Disposition of [G-(3)H]paclitaxel and cremophor EL in a patient with severely impaired renal function. Drug Metab Dispos. 27(11):1300-1305  PMID 10534315

Gueritte-Voegelein F, Senih V, David B, Guenard D and Potier P (1986)  Chemical studies of 10-deacetyl baccatin III: Hemisynthesis of taxol derivatives. Tetrahed. 42(16):4451-4460

Kant J et al (1994)  A chemoselective approach to functionalize the C-10 position of 10-deacetylbaccatin III. Synthesis and biological properties of novel C-10 Taxol® analogues. Tetrahed. Lett. 35(31):5543-5546

Ojima I et al (1997)  Syntheses and structure-activity relationships of toxoids derived from 14 beta-hydroxy-10-deacetylbaccatin III. J. Med. Chem. 40(3):267-278  PMID 9022793

Yukimune Y, Tabata H, Higashi Y and Hara Y (1996)  Methyl jasmonate-induced overproduction of paclitaxel and baccatin III in Taxus cell suspension cultures. Nature Biotechnol. 14(9):1129-1132

Available Documents

• SDS
• Product Data Sheet