Nemadectin is a natural substance with broad-spectrum endectocidal, nematicidal and insecticidal activity. It is a macrocyclic lactone that is structurally similar to milbemycin and avermectin antibiotics, differing by the unsaturated side-chain extending from the 6,6-spiroketal core. This antiparasitic agent can be used as a starting material for the production of Moxidectin.
|Mechanism of Action||Nemadectin binds to the ion channels that are needed for invertebrate nerve and muscle cell function. This leads to an increase permeability leading to an influx of chloride ions and parasite paralysis.|
|Spectrum||Nemadectin is broad-spectrum antiparasitic agent effective against nematodes and insects. It has activity against the major canine gastrointestinal helminthes.|
Carter GT et al (1988) LL-F28249 antibiotic complex: A new family of antiparasitic macrocyclic lactones. Isolation, characterization and structures of LL-F28249 alpha, beta, gamma, lambda. J Antibiot (Tokyo). 41(4):519-529 PMID 337235
Doscher ME, Wood IB, Pankavich JA, Ricks CA (1989) Efficacy of Nemadectin, a new broad-spectrum endectocide, against natural infections of canine gastrointestinal helminths. Vet Parasitol. 34(3):255-259 PMID 2617829
Ling-Yu Yang L et al (2013) New nemadectin congeners with acaricidal and nematocidal activity from Streptomyces microflavus neau3 Y-3, Bioorg. Med. Chem. Lett. 23 (20):5710-5713