SKU: M063  / 
    CAS Number: 18378-89-7

    Mithramycin A

    $83.00 - $289.00
    Mithramycin A was the first of the aureolic acid class of antitumor antibiotics, isolated from Streptomyces.

    Mithramycin A is soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
    Mechanism of ActionMithramycin inhibits transcription and protein synthesis by non-covalent binding with G-C-rich duplex DNA in the presence of magnesium and zinc ions. Mithramycin also induces differentiation of leukemic cells accompanied by an early decrease in c-myc expression, and selectively inhibits collagen-1 gene expression in human fibroblasts.
    ReferencesAureolic acid, a new antibiotic. I. Microbiological studies. Grundy W. E. et al. Antibiot. Chemother. 1953, 2, 1215.

    Aureolic acid group of anti-tumor antibiotics. Berlin Y. U. et al. Nature 1968, 218, 193.

    Mithramycin selectively inhibits the transcriptional activity of a transfected human c-myc gene Ray R. et al. Am. J. Med. Sci. 1990, 300, 203.

    Interaction of mithramycin with DNA. Evidence that mithramycin binds to DNA as a dimer in a right-handed screw conformation. Demicheli C. et al. Eur. J. Biochem. 1991, 198, 333.

    Mithramycin selectively inhibits collagen-alpha 1(I) gene expression in human fibroblast. Nehls M. C. et al. ; J. Clin. Invest. 1993, 92, 2916