Etoposide is an anticancer topoisomerase inhibitor that was derived from the natural product podophyllotoxin extracted from Podophyllum peltatum. It is effective against a variety of cancers, causing DNA damage which leads to apoptosis.
Etoposide is very slightly soluble in water.
Etoposide is very slightly soluble in water.
Mechanism of Action | Etoposide targets DNA topoisomerase II, hindeirng the re-ligation step of DNA replication. This causes DNA damage and leads the cell to programmed cell death. |
References | Montecucco, A., Zanetta, F., & Biamonti, G. (2015). Molecular mechanisms of etoposide. Experimental and Clinical Sciences, 14, 95-108. doi:10.17179/excli2015-561 |