SKU: E040  / 
    CAS Number: 139601-96-0

    Enopeptin A

    $239.50 - $837.50

    Enopeptin A is an unusual depsipeptide featuring a pentaenone side chain, reported as an antiviral by researchers at RIKEN in 1991. Enopeptin A has potent antibacterial activity against Gram-positive and Gram-negative bacteria, including MRSA. Enopeptin A is the most non-polar of the acyldepsipeptide (ADEP) antibiotics which include the recently rediscovered compounds, A54556 A and B.

    Enopeptin A is soluble in ethanol, methanol, DMF or DMSO.

    Mechanism of Action Like other acyldepsipeptide (ADEP) antibiotics, Enopeptin A acts by activating and disregulating Clp-family proteins.
    Molecular Formula C47H57N7O11

    Hinzen B et al (2006)  Medicinal chemistry optimization of acyldepsipeptides of the enopeptin class antibiotics. . Chem. Med. Chem. 1:689

    Koshino H. et al (1991)  The structure of enopeptins A and B, novel depsipeptide antibiotics. Tetrahedron Letters 32:7707

    Lee B-G. et al (2010)  Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism. Nature Struct. Mol. Biol. 17:471

    Osada H. et al (1991)  Enopeptin A, a novel depsipeptide antibiotic with anti-bacteriophage activity.  J. Antibiot. 44:1436