SKU: D033  / 
    CAS Number: 62013-04-1


    Dirithromycin is a macrolide antibiotic pro-drug of 9S-erythromycylamine, a close analogue of erythromycin in which the 9-keto group is replaced with an amino group in the S-configuration. Although erythromycylamine overcomes the acid instability of erythromycin, it is poorly absorbed following oral administration. Dirithromycin is formed by reacting erythromycylamine with an aldehyde to form a Schiff base which undergoes cyclisation to an oxazine with the C11-alcohol. Dirithromycin provides higher tissue levels and prolonged in vivo half-life by slowly releasing erythromycylamine.

    Dirithromycin is soluble in ethanol, methanol, DMF and DMSO. 
    Molecular FormulaC42H78N2O14
    ReferencesSynthesis and antimicrobial evaluation of dirithromycin (AS-E 136: LY237216), a new macrolide antibiotic derived from erythromycin. Counter F.T. et al. Antimicrob. Agents Chemother. 1991, 35, 1116. 

    Dirithromycin: Introduction and historical development. Kirst H.A. Drugs Today 1995, 31, 89.