SKU: C220

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Description
Cyclo(Δ-Ala-L-Val) is a diketopiperazine formed by the fusion of Δ-alanine and valine, reported as a secondary metabolite of fungi and bacteria. In Pseudomonas aeruginosa, cyclo(Δ-Ala-L-Val) is capable of activating N-acylhomoserine lactones (AHLs). Cyclo(Δ-Ala-L-Val) is also capable of activating or antagonizing other LuxR-based quorum-sensing systems.

Cyclo(Δ-Ala-L-Val) is soluble in ethanol, methanol, DMF or DMSO. Limited water solubility

    CAS Number

    25516-00-1

    Molecular Formula

    C8H12N2O2

    Molecular Weight

    168.1

    Mechanism of Action

    While the mode of action of cyclo(Δ-Ala-L-Val) is not known, its activity suggests the existence of cross talk among bacterial signalling systems.

References

    References

    Quorum-sensing cross talk: isolation and chemical characterization of cyclic dipeptides from Pseudomonas aeruginosa and other Gram-negative bacteria. Holden M.T.G. et al. Mol. Microbiol. 1999, 33, 1254.

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