SKU: A110  / 
    CAS Number: 95398-45-1

    A 54556A

    $239.50 - $837.50
    A 54556A is an unusual depsipeptide isolated from Streptomyces hawaiiensis by researchers at Eli Lilly in 1985, featuring a trienone side chain. A 54556A is potently active against Gram positive and Gram negative bacteria, including MRSA. ADEPs are considered important leads in the development of new generations of antibiotics against resistant bacteria.

    A 54556A is soluble in ethanol, methanol, DMF and DMSO.
    Mechanism of ActionA 54556A acts by activating and dis-regulating Clp-family proteins.
    Molecular FormulaC38H50N6O8
    ReferencesA54556 antibiotics and process for production thereof. Michel K.H. and Kastner R.E. U.S. Patent 4,492,650 1985.

    Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism. Lee B-G. et al. Nat. Struct. Molec. Biol. 2010, 17, 471.

    Antibiotic acyldepsipeptides activate ClpP peptidase to degrade the cell division protein FtsZ. Sass P. et al. PNAS 2011, 108, 17474.