• Zotarolimus packaged and labeled in glass vial.

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SKU: Z013

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Description
Zotarolimus is a semi-synthetic macrocyclic lactone prepared from rapamycin by preparation of the 42-triflate ester, followed by displacement with tetrazole and purification of the two isomeric products. This structural change affords a less bioavailable product, a preferred profile for some applications. Zotarolimus is extensively cited in the literature with over 200 citations.

    CAS Number

    221877-54-9

    Molecular Formula

    C52H79N5O12

    Molecular Weight

    966.2

    Mechanism of Action

    Zotarolimus binds to a receptor protein (FKBP12). The complex then binds to mTOR preventing it from interacting with target proteins.

Specifications

    Appearance

    White solid

References

    References

    Compositions, systems, and kits for administering zotarolimus and paclitaxel to blood vessel lumens. Burke S.E. et al. US Patent 7,357,942, 2008.


    Zotarolimus, a novel sirolimus analogue with potent anti-proliferative activity on coronary smooth muscle cells and reduced potential for systemic immunosuppression Chen Y.W. et al. J. Cardiovasc. Pharmacol. 2007, 49, 228.

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