SKU: V022

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Description
Virginiamycin complex is defined as a mixture of 75% ostreogrycin A (virginiamycin M1) and 25% virginiamycin S1, together with the less abundant S analogues. As the two major components have quite different solubilities, these proportions are not readily achieved or used. The composition of the complex is important as Virginiamycin S1 acts a synergist, binding to the conformational change of the peptidyl transferase centre of the 50S ribosome induced by ostreogrycin A.

Virginiamycin is soluble in DMF and DMSO.

    CAS Number

    11006-76-1

    Molecular Formula

    C28H35N3O7 (for M1), C43H49N7O10 (for S1)

    Molecular Weight

    525.6 (for M1); 823.9 (for S1)

    Storage Conditions

    -20°C

Specifications

    Appearance

    White solid

References

    References

    The structures of the minor components of virginiamycin S. Vanderhaeghe, H. et al. , Tet. Lett. 1971, 2687.

    Virginiamycin: nomenclature. Crooy P. and De Neys R. J. Antibiot. 1972, 25, 371.

    A new species of Streptomyces producing virginiamycin family antibiotics. Ogata, K. et al. , J. Antibiot. 1978, 31, 1313.

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