SKU: V022

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Virginiamycin complex is defined as a mixture of 75% ostreogrycin A (virginiamycin M1) and 25% virginiamycin S1, together with the less abundant S analogues. As the two major components have quite different solubilities, these proportions are not readily achieved or used. The composition of the complex is important as Virginiamycin S1 acts a synergist, binding to the conformational change of the peptidyl transferase centre of the 50S ribosome induced by ostreogrycin A.

Virginiamycin is soluble in DMF and DMSO.

    CAS Number


    Molecular Formula

    C28H35N3O7 (for M1), C43H49N7O10 (for S1)

    Molecular Weight

    525.6 (for M1); 823.9 (for S1)

    Storage Conditions




    White solid



    The structures of the minor components of virginiamycin S. Vanderhaeghe, H. et al. , Tet. Lett. 1971, 2687.

    Virginiamycin: nomenclature. Crooy P. and De Neys R. J. Antibiot. 1972, 25, 371.

    A new species of Streptomyces producing virginiamycin family antibiotics. Ogata, K. et al. , J. Antibiot. 1978, 31, 1313.

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