• Venturicidin B, EvoPure� packaged and labeled in glass vial.

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SKU: V018

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Description
The macrolide antibiotic Venturicidin B, isolated from a Streptomyces sp., is a potent inhibitor of mitochondrial ATP synthase complex acting on the F0 membrane sector. Venturicidin B was originally isolated as an antifungal agent.

Venturicidin B is soluble in ethanol, methanol, DMF and DMSO. 

    CAS Number

    33538-72-6

    Molecular Formula

    C40H66O10

    Molecular Weight

    707.0

    Storage Conditions

    -20°C

Specifications

    Appearance

    White Lyophilisate

References

    References

    Studies on the mechanism of oxidative phosphorylation. ATP synthesis by submitochondrial particles inhibited at F0 by venturicidin and organotin compounds. Matsuno-Yagi A. & Hatefi Y. J. Biol. Chem. 1993, 268, 6168.

    Potassium selective and venturicidin sensitive conductances of Fo purified from bovine heart mitochondria, reconstituted in planar lipid bilayers. Miedema H. et al. Biochem. Biophys. Res. Commun. 1994, 203, 1005.

    Amino acid substitutions in mitochondrial ATP synthase subunit 9 of Saccharomyces cerevisiae leading to venturicidin or ossamycin resistance. Galanis M. et al. FEBS Lett. 1989, 249, 333.

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