• UK-1 packaged and labeled in glass vial.

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SKU: U007

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Description
UK-1 is an unusual bis-benzoxazole metabolite isolated from a species of Streptomyces. UK-1 exhibits good antitumor activity but is devoid of antimicrobial activity.

    CAS Number

    151271-53-3

    Molecular Formula

    C22H14N2O5

    Molecular Weight

    386.4

    Mechanism of Action

    UK-1 acts as a magnesium ion-dependent DNA binding agent and inhibitor of human topoisomerase II.

    Storage Conditions

    -20°C

Specifications

    Appearance

    White to pale pink solid

References

    References

    UK-1, a novel cytotoxic metabolite from Streptomyces sp. 517-02. I. Taxonomy, fermentation, isolation, physicochemical and biological properties. Ueki M. et al. J. Antibiot. 1993, 46, 1089. 

    UK-1, a novel cytotoxic metabolite from Streptomyces sp. 517-02. II Structure elucidation. Shibata K. J. Antibiot. 1993, 46, 1095. 

    The novel bis(benzoxazole) cytotoxic natural product UK-1 is a magnesium ion-dependent DNA binding agent and inhibitor of human topoisomerase II. Reynolds M. B. et al. Bioorg. Chem. 1999, 27, 326.

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