• Tylosin packaged and labeled.

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SKU: T013

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Description

Tylosin is a broad spectrum bacteriostatic macrolide antibiotic and is commonly used in veterinary medicine.

    CAS Number

    1401-69-0

    Molecular Formula

    C46H77NO17

    Molecular Weight

    916.10

    Mechanism of Action

    Macrolide antibiotics inhibit bacterial growth by targeting the 50S ribosomal subunit preventing peptide bond formation and translocation during protein synthesis. Resistance to tylosin is commonly attributed to mutations in 50S rRNA preventing tylosin binding allowing the cell to synthesize proteins free of error.

    Tariff Code

    2941.90.1010

    Spectrum

    Tylosin targets primarily gram positive bacteria and species of the Mycoplasma genus.

Applications

    Microbiology Applications

    Tylosin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and Mycoplasma microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Mycoplasma hyopneumoniae 0.015 µg/mL – 0.3 µg/mL
    • Streptococcus pneumoniae 0.125 µg/mL - 64 µg/mL
    • For a complete list of tylosin MIC values, click here.

Specifications

    Appearance

    Almost white or slightly yellow powder

    pH

    8.5 - 10.5

    Assay

    ≥ 900 IU/mg (on dried basis)

    Loss on Drying

    ≤5.0%

    Sulfated Ash

    ≤3.0%

    Impurities

    Tyramine: ≤3.5%

References

    References

    Lovmar, Martin, and Tanel Tenson. "The Mechanism of Action of Macrolides, Lincosamides and Streptogramin B Reveals the Nascent Peptide Exit Path in the Ribosome."Journal of Molecular Microbiology 330.5 (2003): 1005-014.

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