• Trinactin packaged and labeled in glass vial.

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SKU: T101

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Description
Trinactin is a member of the macrotetrolide complex produced by a range of Streptomyces sp.. Early literature reported that trinactin was a monovalent cation ionophore with high selectivity for ammonium and potassium. Trinactin has not previously been available for intensive investigation.

Trinactin is soluble in ethanol, methanol, DMF and DMSO.

    CAS Number

    7561-71-9

    Molecular Formula

    C43H70O12

    Molecular Weight

    779.0

    Mechanism of Action

    Trinactin inhibits T-cell proliferation induced by IL-2, and cytokine production at nanomolar levels for IL-2, IL-4, IL-5 and interferon-γ.

    Storage Conditions

    -20°C

Specifications

    Appearance

    Colourless Film

References

    References

    Effects of cyclosporin A and dinactin on T-cell proliferation, interleukin-5 production, and murine pulmonary inflammation. Umland S. P., et al. , Am. J. Respir. Cell Mol. Biol., 1999, 20, 481.

    Immunosuppressive effects of polynactins (tetranactin, trinactin and dinactin) on experimental autoimmune uveoretinitis in rats. Tanouchi Y., et al. , Jpn. J. Ophthalmol., 1987, 31, 218.

    Antibiotics as tools for metabolic studies. VI. Damped oscillatory swelling of mitochondria induced by nonactin, monactin, dinactin, and trinactin. Graven S. N., et al. , Biochemistry, 1966, 5, 1735.

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