• Tigecycline packaged and labeled.

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SKU: T022

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Description

Tigecycline is a broad spectrum glycylcycline antibiotic which was developed to combat infections caused by many leading multi-drug resistant organisms. Tigecycline is structurally related to minocycline, a tetracycline antibiotic; however, it contains a large glycylamido group at the D-9 position. This substitution is thought to be the reason behind its broad spectrum activity. Tigecycline is soluble in water (0.45mg/mL) and DMSO (>3 mg/mL).

This product is considered a dangerous good. Quantities above 1 g may be subject to additional shipping fees. Please contact us for specific questions. 

    CAS Number

    220620-09-7

    Molecular Formula

    C29H39N5O8

    Molecular Weight

    585.65

    Mechanism of Action

    Tigecycline inhibits protein synthesis by binding to the A site of the 30S ribosomal subunit.

    Storage Conditions

    -20°C

    Tariff Code

    2941.30.0000

    Spectrum

    Tigecycline has broad spectrum activity against most Gram positive and Gram negative bacteria including multi-drug resistant organisms such as MRSA. Tigecycline has also been found to be effective against carbapenem resistant Enterobacteriaceae or CRE. CRE is a "superbug" which possesses NDM-1 or KPC genes which encode New Delhi Metallo-beta-lacamase or Klebsiella pneumoniae cabapenemase respectively; two enzymes which render nearly all beta-lactam antibiotics useless.

Applications

    Microbiology Applications

    Tigecycline is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram positive and Gram negative microbial isolates. Tigecycline has also shown high potency against high-resistant superbug strains. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    Staphylococcus aureus (methicillin resistant) 0.03 µg/mL-2 µg/mL

    Streptococcus pneumoniae 0.015 µg/mL – 2 µg/mL

    For a complete list of tigecycline MIC values, click here.

Specifications

    Form

    Powder

    Appearance

    Orange to Orange-Red Colored Powder

    Source

    Semi-synthetic

    Impurity Profile

    Bacterial Endotoxin: ≤1.75 EU/mg

    Water Content (Karl Fisher)

    ≤2.0%

    Assay

    (As Is): 98.0-102.0%

    Residue On Ignition

    ≤0.1%

    Heavy Metals

    ≤10ppm

    Residual Solvents

    Meets requirements

References

    References

    Da Silva, L. M, et. al.. "Tigecycline: A Review of Properties, Applications, and Analytical Methods." Therapeutic Drug Monitoring 32.3 (2010): 282-88. Web. 10 Apr. 2013.

    Pankey, George A. "Tigecycline." Journal of Antimicrobial Chemotherapy 56.3 (2005): 470-80. Web. 10 Apr. 2013.

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