• Tiamulin packaged and labeled in glass vial.

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SKU: T091

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Description
Tiamulin is a semi-synthetic analogue of pleuromutilin in which the hydroxyacetyl side chain is replaced with a larger diethylaminoethylthioacetyl moiety, providing greater hydrophobicity and an ionisable group for salt formation and greater water solubility. Tiamulin is a potent and highly selective antibiotic active against a range of Gram positive bacteria, with no cross resistance to existing antibiotic classes due to its unique mode of action. Like pleuromutilin, it inhibits protein synthesis by binding to domain V of 23S rRNA.

Tiamulin is soluble in ethanol, methanol, DMF and DMSO. 

    CAS Number

    55297-95-5

    Molecular Formula

    C28H47NO4S

    Molecular Weight

    493.7

    Storage Conditions

    -20°C

Specifications

    Appearance

    Evaporated resin

References

    References

    New pleuromutilin derivative with enhanced antimicrobial activity. I. Synthesis. Egger H. & Reinshagen H. J. Antibiot. 1976, 29, 915. 

    Pleuromutilin antibiotics. Hunt E. Drugs Future 2000, 25, 1163.

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